CDK4 AMPLIFICATION Detail (hg19) (CDK4)
Information
Genome
| Assembly | Position |
|---|---|
| hg19 | chr12:58,141,510-58,146,304 |
| hg38 | chr12:57,747,727-57,752,521 View the variant detail on this assembly version. |
Summary
MGeND
| Clinical significance | |
| Variant entry | |
| GWAS entry | |
| Disease area statistics | Show details |
ClinVar
| Clinical Significance | |
| Review star | [No Data.] |
| Show details | |
Disease area statistics
[No Data.]
MGeND
[No Data.]
ClinVar
[No Data.]
CIViC
| Disease | Drug | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| liposarcoma | Palbociclib | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 23569312 | Detail |
| liposarcoma | Palbociclib | B |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 27124835 | Detail |
DisGeNET
[No Data.]
Annotation
Annotations
| Descrption | Source | Links |
|---|---|---|
| In a phase 2 clinical trial, NCT01209598, 30 patients with CDK4-amplified and RB-expressing well dif... | CIViC Evidence | Detail |
| More than 90% of well-differentiated or dedifferentiated liposarcomas (WD/DDLS) have CDK4 amplificat... | CIViC Evidence | Detail |
Overlapped Transcript Coordinates
| Gene | Transcript ID | Exon Number | Chromosome | Start | Stop | Type | Amino Mutation | Transcript Position | Links |
|---|
Overlapped Transcript
| Gene | Transcript ID | Chromosome | Start | Stop | Links |
|---|
- Gene
- CDK4
- Genome
- hg19
- Position
- chr12:58,141,510-58,146,304
- Variant Type
- cnv
- Variant (CIViC) (CIViC Variant)
- AMPLIFICATION
- Transcript 1 (CIViC Variant)
- ENST00000257904.6
- Variant URL (CIViC Variant)
- https://civic.genome.wustl.edu/links/variants/553
Genome browser